Final program 2018
Last update: 21.01.2018
*All abstract submissions are eligible to present a poster at the meeting (including the ones that in addition have been chosen for a talk)*
You can find below:
- The final meeting booklet - available for download or below as "scrollable version"
- Also check out our special sessions here: www.annual-meeting.ls2.ch/2018/program/special-sessions
| Monday | 12.02.2018 |
| 08:00 – 09:00 | Registration, Welcome Coffee, Mounting of Posters |
| 09:00 – 09:10 | Welcome Address Jean Gruenberg (President of LS2) |
| 09:10 – 10:00 | Plenary Lecture I Autophagy: Its Membrane Dynamics and Implications in Diseases Autophagy is an evolutionarily conserved membrane trafficking from the cytoplasm to lysosomes. In autophagy, autophagosomes transiently emerge in the cytoplasm, sequester substrates, and eventually fuse with lysosomes to degrade the contents. In addition to nutrient supply under starvation conditions, the process functions in suppression of various diseases including infectious diseases, tumorigenesis, neurodegeneration, type 2 diabetes, etc. My group has been working on unraveling the molecular machinery and roles of mammalian autophagy. LC3, a first protein we identified, has been mostly used golden marker in autophagy studies. Recently, we have provided new insights into biogenesis of autophagosome, which have been topic of longstanding debate. We showed that autophagosome forms at the ER-mitochondria contact site. We also found that autophagy selectively eliminates invading pathogenic bacteria, opening a new field on host-pathogen interaction. Then, we unraveled how autophagy recognizes bacteria. We also found that autophagy suppresses nephropathy through selective elimination of damaged lysosomes. I also discuss about our recent finding that high fat diet increases the amount of a negative regulator of autophagy, Rubicon, which we identified. Knockout of the gene dramatically improved non-alcoholic fatty liver disease in mice fed high fat diet. Hide text… |
| 10:00 – 10:05 | Teaser: Crowdfunding Science Session Mirko Bischofberger (science.wemakeit.com) |
| 10:05 – 10:30 | Coffee Break, Industry Exhibition, Poster Viewing |
| 10:30 – 12:30 | Parallel Symposia I |
Inflammation in Chronic Pathologies by LS2 Section Molecular and Cellular Biosciences
Chair: Jean-Claude Martinou (University of Geneva)
Peter Vandenabeele (Ghent University, BE) Fabio Martinon (University of Lausanne) Marie Kosco-Vilboi (Novimmune SA)
Speakers from abstracts Rosalie Heilig (University of Lausanne) “The Gasdermin-D pore acts as a conduit for IL-1β secretion” Jimit Shah (University of Geneva) “Junctional clustering of ADAM10 and its interactor Tetraspanin33 by the PLEKHA7-PDZD11 complex promotes cytotoxicity by Staphylococcus aureus α-toxin” Evgeniya Trofimenko (University of Lausanne) “Potassium channels and membrane polarization control membrane translocation of cell-penetrating peptides” Kateryna Shkarina (University of Lausanne) “Optogenetic control of inflammasome assembly and cell death” | |
Dynamics of the Actin Cortex Physics of Biology
Chair: Karsten Kruse (University of Geneva)
Elisabeth Fischer-Friedrich (Technical University Dresden, DE) Guillaume Charras (University College London, UK) Elmar Hartmann (JPK Instruments AG)
Francesco Atzeni (University of Zurich) “Mechanochemical modelling as an explorative tool to study tissue morphogenesis”
Qian Feng (ETH Zurich) “Mitochondria squeezed – mechanically induced mitochondrial fission” Caroline Arous (University of Geneva) “Analysis of the adhesion-mediated control of insulin secretion in response to glucose and autocrine insulin/IGF2-signaling in pancreatic β-cells” | |
Tomorrow's PIs - the Future of Swiss Research Special session
Chairs: Nino Nikolovski, Aleksandra Konovalova & Elisa Araldi This session offers an opportunity to postdocs and senior researchers interested in pursuing an academic career to present a talk similar in format to a professorship application interview. A knowledgeable jury panel of professors will evaluate the presentations and provide feedback in a one-on-one session afterward. Our finalists of the 2018 edition are: Petra Schwalie, EPF Lausanne Jury members of the session Paola Picotti (ETH Zurich) Please check the menu bar "PIs of Tomorrow" for more information and the applicants' abstracts. | |
| 12:30 – 13:45 | Lunch Break, Industry Exhibition, Poster Viewing |
| 12:30 – 13:30 | LS2 Molecular & Cellular Biosciences Section Board Meeting |
| 12:30 – 13:30 | SSEP Board Meeting Upon invitation only |
| 12:40 – 13:45 | Lunch Careers Roundtables I Non-Academic Careers in the Life Sciences Chair: Courtney Thomas (EPF Lausanne) Invited speakers: Lisa Pollaro, Chief Operating Officer, Nanolive |
| 13:45 – 15:45 | Parallel Symposia II |
Molecular Logic of Brain Circuits by Swiss Society for Neurosciences (SSN)
Chair: Csaba Földy (University of Zurich)
Joris de Wit (University of Leuven, BE) Simon Hippenmeyer (Institute of Science and Technology Austria) Peter Nestorov (Witec AG)
Chaim Gluck (University of Zurich) “Calcium Signaling in Pericytes” Marieke Hoekstra (University of Lausanne) “Cold-Inducible RNA Binding Protein (CIRBP) contributes to quality of waking, REM sleep homeostasis and refines the cortical molecular response to sleep deprivation“ Baptiste Jaeger (University of Zurich) “Hippocampal single-nucleus sequencing identifies a unique transcriptional signature that is predictive of reactivity in dentate granule neurons” Valérie Panneels (Paul-Scherrer-Institut (PSI) Villigen) “3D-imaging of neuronal layers in retina tissue from wild-type and retinitis pigmentosa model using cryo X-ray nanotomography” | |
The Emerging Field of Immunometabolism by Swiss Society of Experimental Pharmacology (SSEP)
Chair: Carole Bourquin (University of Geneva)
Hongbo Chi (St. Jude Children’s Research Hospital Memphis, US) Ping-Chih Ho (University of Lausanne) Kathrin Pieles (Bucher Biotec AG) Tools for immediate early T cell activation and high-throughput phenotype analysis, enabling new immuno-oncology insights
Tanja Eberhart (ETH Zurich) “Development of tools to study the effect of decreased peroxisome abundance on tumorigenesis” Quentin Haas (University of Bern) “Glycan-Checkpoint Inhibitor unleashing CD8+ T cells against Cancer” Narashima Rao Uda (University of Geneva) “Targeting lipid metabolism to improve cancer immunotherapy” Marc Chanson (University of Geneva) “Dendritic cell migration towards CCL21 requires functional Cx43” | |
Dynamics of Cellular Signalling Complexes by LS2 Section Physiology
Chair: Nicolas Demaurex (University of Geneva)
Christian Ungermann (University of Osnabrück, DE) Sergio Grinstein (University of Toronto, CAN) Andreas Wiederkehr (Nestlé Institute of Health Sciences, CH)
Laure-Anne Ligeon (University of Zurich) “Molecular mechanisms of LC3-associated phagocytosis during MHC class II presentation” Andrea Picco (University of Geneva) “The contributions of the actin machinery to endocytic membrane bending and vesicle formation” Echrak Hichri (University of Bern) “Ephaptic coupling in the heart is potentiated by the distribution of sodium channels in clusters in the intercalated disc” Vaibhav Wasnik (University of Geneva) “Positional information readout in Ca2+ signaling”
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| 15:45 – 16:15 | Coffee Break, Industry Exhibition, Poster Viewing |
| 16:15 – 16:45 | Friedrich-Miescher-Award The jury committee of the Friedrich-Miescher-Award has selected two winners for 2018:
Paola Picotti (ETH Zurich) “Probing protein structural changes on a proteome-wide scale”
Marek Basler (University of Basel) “Bacterial Type VI secretion system: from structure to dynamics and function”
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| 16:45 – 17:30 | Plenary Lecture II Molecular Mechanisms of Autophagosome Formation Autophagy (self-eating) maintains cellular homeostasis and survival, and combats disease and infection. Under the control of multiple signalling pathways autophagosomes sequester and deliver cytosolic material to the lysosome for degradation thus mediating autophagy. This rapid, dynamic process is orchestrated by a highly conserved set of proteins called the ATG (Autophagy-related) proteins, in addition to protein families involved in protein trafficking and secretion. These proteins act in a coordinated fashion, to ultimately remobilize proteins and lipids to autophagosome formation sites. My lab aims to understand how autophagosomes form under stress conditions such as amino acid starvation, with the goal to understand at a molecular level this process and autophagy. We focus on key initiating ATG proteins, including the multi-spanning membrane protein ATG9, the ULK kinases, and the PI3P effectors, the WIPIs, to understand how autophagosomes form, and how this process is regulated. Our work also aims to understand the role of protein trafficking complexes, cellular compartments, in particular the Golgi complex, endosomes, the centrosome, and membrane contact sites in the process of autophagosome formation. A more complete molecular understanding of this process will provide key knowledge to develop therapies to manipulate autophagy to improve human health and prevent disease. Hide text… |
| 17:30 – 18:30 | Candies, LSD and Crowdfunding Crowdfunding Science Session Featuring the incredible LSD research story of Robert Carhart-Harris and David Nutt and more successful projects from the first Swiss science crowdfunding channel, science.wemakeit.com: Introduction Keynote lecture Natalie Jonk (CEO at CrowdScience, London, UK) The viral LSD crowdfunding campaign Two project presentations from science.wemakeit.com 1. HORAO 2. At The Heart of Congo Kids |
| 18:30 – 20:30 | Poster Session & Big Apéro in the Industry Exhibition Area 18:30 - 19:30: Even poster numbers |
| 19:30 – 20:15 | LS2 Delegates Assembly Upon invitation only |
| Tuesday | 13.02.2018 |
| 09:00 – 09:50 | Plenary Lecture III: 'The FEBS National Lecturer' A Cross-Talk Between Lysosome and Nucleus Controls Cell Metabolism In the early 50s, Christian De Duve identified a new cellular structure, the lysosome, defined as the cell’s “suicide bag”. Sixty years later, it is clear that the lysosome greatly exceeded the expectations of its discoverer. Over 50 different types of lysosomal storage diseases have been identified, each due to the deficiency or malfunction of a specific lysosomal protein. In addition, an important role of the lysosome has been unveiled in several common human diseases, such as cancer, obesity, neurodegenerative diseases, and infection. Recent studies in our lab have led to the identification of a lysosomal gene network and a master gene, TFEB, which regulate lysosomal biogenesis and autophagy. The activity of TFEB is controlled by the mTORC1 kinase complex through a lysosomal signaling pathway. Recently, we discovered a feedback mechanism by which TFEB in turn controls mTORC1 activity. This mechanism plays an important role in the response to starvation and to physical exercise and is deregulated in cancer. These data reveal that the lysosome acts as a signaling hub that controls cell homeostasis and the transition between biosynthetic and catabolic pathways. Hide text… |
| 09:55 – 10:00 | A Word from the Chairman of the Meeting |
| 10:00 – 10:30 | Coffee Break, Industry Exhibition, Poster Viewing |
| 10:30 – 12:30 | Parallel Symposia III |
Systems Biology by SystemsX.ch
Chair: Bart Deplancke (EPF Lausanne)
Stirling Churchman (Harvard University, US) Nadine Vastenhouw (MPI-CBG Dresden, DE) Eavan Dorcey (SystemsX.ch) & Vassily Hatzimanikatis (EPF Lausanne)
Peter Blattmann (ETH Zurich) “Systems pharmacology dissection of cell-specific cholesterol regulation mechanisms reveals large pharmacodynamic variability” Anush Chiappino-Pepe (EPF Lausanne) “Identifying and targeting key cellular mechanisms for proliferation in Plasmodium parasites: a combined experimental and computational strategy” Ilaria Piazza (ETH Zurich) “A map of metabolite-proteins interactions on a system-wide scale” Yolanda Schaerli (University of Lausanne) “The mechanisms of gene regulatory networks constrain evolution: A lesson from synthetic stripe-forming circuits” | |
Novel Regulatory Mechanisms in Autophagy and Apoptosis by LS2 Section Autophagy
Chairs: Mario Tschan (University of Bern) & Jörn Dengjel (University of Fribourg)
Thomas Kaufmann (University of Bern) Elena Cardenal Muñoz (University of Geneva) Pathogenic mycobacteria manipulate the xenophagy defence of their amoeba host
Beatrice Paola Festa (University of Zurich) “Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney” Magali Humbert (University of Bern) “Chaperone-Mediated Autophagy Supports the Immature Phenotype of Acute Myeloid Leukemia Cells” Marisa Loi (IRB Bellinzona) “Investigation of the molecular mechanisms regulating recovER-phagy in mammalian cells” Maria Pena-Francesch (University of Zurich) “Involvement of autophagy in Epstein-Barr virus envelope acquisition” Iwona Pilecka (University of Geneva) “CRISPR/Cas9 genome-wide screen to identify players in mitochondrial homeostasis” | |
A Transdisciplinary Panel on CRISPR/Cas9 A FEBS Science & Society funded Science Policy Session
The CRISPR/Cas9 revolution is widely being talked about these days. Apart from being a major scientific breakthrough, it also reveals how different fears and hopes are being handled by science, society, economy, and policy makers. The CRISPR/Cas9 system thus represents an ideal case to discuss the different implications of modern biomedical research, from economical, legal and ethical implications, to aspects of scientific impact and careers. The transdisciplinary panel will give the stage to experts from different fields to then discuss all these aspects around one technology. with: Martin Jinek (University of Zurich) Moderation: Nik Walter (Tages-Anzeiger/SonntagsZeitung) | |
| 12:30 – 14:00 | Lunch Break, Industry Exhibition, Poster Viewing |
| 12:40 – 14:00 | Lunch Careers Roundtables II Neither Academia nor Industry: Careers out of the Box Chair: Fanny Georgi (University of Zurich) Invited speakers Joachim Schnabl, Science Communication ETH Zürich, D-CHAB |
| 12:40 – 13:10 | LS2 General Assembly All members are welcome to join the General Assembly. An invitation with the agenda points will be sent out at least one month before the meeting.
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| 14:00 – 16:00 | Parallel Symposia IV |
Host Pathogen Interactions by LS2 Section Molecular and Cellular Biosciences
Chair: Volker Heussler (University of Bern)
Dominique Soldati-Favre (University of Geneva) Andreas Müller (University of Magdeburg, DE) Luca Clario (Nanolive SA)
Charlotte Montespan (University of Zurich) “Role of autophagy during Kaposi's sarcoma-associated herpesvirus (KSHV) entry” Saori Yoshii (University of Lausanne) “Investigation on the ubiquitination mechanisms for xenophagy induction” Caroline Barisch (University of Geneva) “Take it with a pinch of salt! Zinc intoxication to control mycobacteria infection!” Vivek Thacker (EPF Lausanne) “Lung-on-a-chip microtechnologies for studies of host-pathogen interactions in M. tuberculosis infections” | |
Bioinformatics & Computational Biology : An Evolving Field by Swiss Institute of Bioinformatics
Chair: Ioannis Xenarios (Swiss Institute of Bioinformatics, Lausanne)
Mark Robinson (University of Zurich) Alexander Lachmann (Mount Sinai Center for Bioinformatics, NY, US) Ioannis Xenarios (Swiss Institute of Bioinformatics, Lausanne)
Adithi Varadarajan (ETH Zurich) “An integrative approach to identify the entire protein coding potential of prokaryotic genomes by proteogenomics” Marco Pagni (Swiss Institute of Bioinformatics, Lausanne) “An integrative approach to analysis of omics data and condition-specific metabolic networks” Alan Bridge (Swiss Institute of Bioinformatics, Lausanne) “The SwissLipids knowledge resource for lipid biology“ | |
Host Protein Networks During Pathogen Infection by LS2 Section Proteomics
Chairs: Gisa Gerold (Centre for Experimental and Clinical Infection Research GmbH, Hannover, DE) & Bernd Wollscheid (ETH Zurich)
Gisa Gerold (Centre for Experimental and Clinical Infection Research GmbH, Hannover, DE) Ben Collins (ETH Zurich) Maria Pavlou (Dualsystems Biotech AG) Speakers from abstracts Christian Feller (ETH Zurich) “Characterization of epigenetic inhibitors by histone epi-proteomics technology” Charlotte Nicod (ETH Zurich) “Host proteome modulation upon Mycobacterium tuberculosis infections” Emanuela Milani (ETH Zurich) “HBx: Hepatitis B Virus Swiss Army knife for survival“ Silke Stertz (University of Zurich) “Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as novel antiviral drug target“ | |
| 16:00 – 16:30 | Coffee Break, Industry Exhibition, Poster Viewing |
| 16:30 – 17:15 | Award Ceremonies Tomorrow's PI Award (jury and public prize) Poster Prizes:
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| 16:45 – 17:15 | Plenary Lecture IV Lelio Orci Award Lecture 09.01.2018: The winner of the Lelio Orci Award 2017 is Michael Hall (Biozentrum, University of Basel). The title of his talk is: "mTOR signaling in growth and metabolism" |
| 17:15 – 18:00 | Plenary Lecture V Role of Autophagy Genes in Inflammation and Immunity To understand how autophagy (Atg) genes control immunity we systematically analyzed the role of core Atg genes in macrophages and other myeloid cells in control of inflammation, infection and immunity in vivo. Atg genes are essential for controlling replication of some pathogens in a cell-intrinsic manner and for the control of the inflammatory phenotype of macrophages. Interestingly, this key physiological role of Atg genes is cell type- and stimulus-specific. Despite clear data from such loss-of-function studies in vivo for the role of Atg gene functions in control of infection and inflammation, the cellular mechanisms for these effects are not clear. To define the molecules involved in Atg gene-dependent regulation of macrophage activation we have performed whole genome CRISPR-Cas9-based screens. These studies reveal a series of candidate cellular pathways potentially regulated by core Atg genes. In addition, we have revisited a previously published demonstration that Atg5, Atg7, Atg16L1 and the conjugation of Atg5 to Atg12 (but not Atg14 or degradative autophagy) are required for the control of murine norovirus (MNoV) replication by the key anti-viral cytokine interferon-γ (IFNγ). We constructed a BV2 microglial cell line expressing BirA*-tagged Atg5. Comparison of Atg5-adjacent proteins in the presence or absence of IFNγ revealed candidate proteins for participating in IFNγ-driven intracellular anti-viral immunity. Of these candidates, to date we have confirmed a role for IRGM1 (also LRG-47 in the mouse) and WIPI-2 in IFNγ-mediate control of MNoV replication. Use of CRISP-CAS9-driven knockout of additional genes thus reveals a cassette of autophagy pathway-related genes that are key for IFNγ-driven intracellular anti-viral immunity. The implications for understanding the role of autophagy and the non-canonical functions of Atg genes in infection and inflammation will be discussed. Hide text… |
| 18:00 – 18:10 | Closing Remarks Jean Gruenberg (President of LS2) |
Special Sessions
Free Public Panel Discussion: A Transdisciplinary Panel on CRISPR/Cas9
A "FEBS Science & Society"-funded Science Policy Session
13.02.2018, 10:30-12:30
The CRISPR/Cas9 revolution is widely being talked about these days. Apart from being a major scientific breakthrough, it also reveals how different fears and hopes are being handled by science, society, economy, and policy makers. The CRISPR/Cas9 system thus represents an ideal case to discuss the different implications of modern biomedical research, from economical, legal and ethical implications, to aspects of scientific impact and careers. The transdisciplinary panel will give the stage to experts from different fields to then discuss all these aspects around one technology.
with:
Martin Jinek (University of Zurich)
Bruno Lemaitre (EPF Lausanne)
Effy Vayena (Chair of Bioethics, Health Ethics and Policy Lab, Department of Health Sciences and Technology, ETH Zurich)
Heinz Müller (Swiss Federal Institute of Intellectual Property, Bern)
Moderation: Nik Walter (Tages-Anzeiger/SonntagsZeitung)
Attendance to the panel only is free.
Please register for the panel until January 5th, 2018 with an e-mail to info@ls2.ch
Full meeting attendance requires registration until January 7th, 2018 via www.annual-meeting.ls2.ch/registration
Science Crowdfunding Session
12.02.2018, 5:30-6:30 pm
"Candies, LSD and Crowdfunding", February 12th, 5.30-6.30 pm:
Featuring the incredible LSD research story of Robert Carhart-Harris and David Nutt and more successful projects from the first Swiss science crowdfunding channel, science.wemakeit.com:
Introduction
Mirko Bischofberger and Luc Henry, science.wemakeit.com
Keynote lecture
Natalie Jonk (CEO at CrowdScience, London, UK)
The viral LSD crowdfunding campaign
2 Short project presentations from science.wemakeit.com
1. HORAO
Prof. Ph. Schucht, Inselspital Bern, https://wemakeit.com/projects/horao
The HORAO project puts the most brilliant minds to work on improving technologies that visualize the exact border between brain tumor and healthy brain through a global prize-based competition!
2. At The Heart of Congo Kids
Prof. H. Abriel und P. Teixidor, Universität Bern, https://wemakeit.com/projects/at-the-heart-of-congo-kids
A pediatric doctor from the University Clinics of Kinshasa (DR Congo) needs to purchase scientific equipment to do his research and get advice from Swiss cardiologists.
