Program

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Tuesday10.02.202612:00 – 19:00

12:00 – 12:30
Registration & Welcome Coffee for Young Scientists' Satellite

Registration will remain open from 12:00 to 18:00

12:30 – 12:35
Welcome Address
12:35 – 12:40
Introduction from YSS Chairs
12:40 – 13:00
YSS Keynote Lecture I
Lara URBAN
University of Zurich, Institutes for Food Safety and Hygiene and for One Health
Visit Urban's Lab Page

More about Lara Urban and this Talk

13:05 – 13:25
YSS Keynote Lecture II
13:25 – 13:55
Coffee Break
13:55 – 15:15
Scientific Symposium

Speakers selected from abstracts (10' + 2' Q&A)

Marta Mazurkiewicz (University of Zurich) 
"Identification of oligodendrocyte transcriptional signatures in Western diet-induced pain"

Annemarie Ianos (Baruch College, City University of New York) 
"Nanoplastics penetration across the blood-brain barrier"

Elena Barletta (Swiss Institute of Bioinformatics) 
"Proteomics Profiling Reveals Sex-Based Differences and Hormonal Modulation of Recovery in Elite Female Athletes Following Intense Exercise"

Jakub Hruby (EPF Lausanne) 
"Microsecond Time-Resolved Cryo-EM Based on Jet Vitrification"

Marta Balkota (University of Geneva) 
"Brain Mitochondrial Glutamate Metabolism Coordinates Body Energy Balance and Age-Related Behavioral Changes"

Justine Leclerc (University of Zurich) 
"conformeR: Conformalized differential expression analysis of multi-condition single-cell data"

15:15 – 15:45
Coffee Break
15:45 – 16:00
Introducing: LS2-supported Student Prize Winners

Victoria Jaël Moser & Mara Robinson (Sonderpreis)
Ruben Kastelic, Raphael Burgener, Lukas Müller, Dhruv Sharma (Biologie Olympiade)

16:00 – 16:10
FEBS Initiatives and Fellowship Opportunities for Young Scientists
16:10 – 17:55
Workshop/Panel Discussion

"Speaking Science, thinking AI"

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In today’s scientific landscape, artificial intelligence is no longer a futuristic concept, but an integral part of research, analysis, and communication. While AI offers powerful tools and efficiencies, its overuse or misuse can lead to errors in data interpretation and scientific outcomes. At the same time, AI opens new avenues for communicating complex science to broader audiences, particularly when scientists struggle to translate their work beyond the lab. This workshop explores critical questions: how much should we rely on AI - not just for the heavy lifting of data processing, but its use in critical aspects of science communication. The workshop is designed to facilitate discussions between young AI users and experienced scientists on use of AI for data processing and science communication. Additionally, we discuss the overarching question of where must the human voice remain irreplaceable?

Panelists: Kristina Thumfart (IACULIS GmbH), Verena Waller (Roland Berger) and Darren Ray Kelly (ETH Zurich).

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17:55 – 18:00
Closing Remarks
18:00 – 19:00
YSS Apéro


Wednesday11.02.202608:15 – 19:20

08:15 – 09:00
Registration & Welcome Coffee

Registration will remain open until 17:00

09:00 – 09:10
Welcome Address
09:10 – 09:45
The EMBO Keynote Lecture

Metabolic rewiring driving metastasis formation

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Metastasis formation is the leading cause of death in cancer patients. We find that metabolic rewiring is a liability of metastasizing cancer cells. For example, we discovered that extracellular remodeling of the metastatic niche, a process essential to metastasis formation, requires a transcriptional-independent regulation via the metabolites. Moreover, we provide knowledge on intratumor heterogeneity of metabolism and its role in pre-metastatic niche and metastasis formation. Thus, we study the metabolism of metastasizing cancer cells with the goal to define novel therapeutic strategies.

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09:45 – 10:15
Lelio Orci 2025 Award Lecture

Introduction by Pierre Cosson

Winner will be announced in early 2026

10:15 – 10:45
Coffee Break & Industry Exhibition
10:45 – 12:30
Special Plenary Session: The PIs of Tomorrow

PIOT finalists: 

Theodora Constantin (University of Basel) 
"Unlocking the full potential of PI3Kα inhibitors for cancer therapy"
 
Juan Cruz Landoni (EPF Lausanne) 
"Charting the spatiotemporal coordination of mitochondrial metabolism in development, disease, and aging"
 
Olimpia Bompadre (EPF Lausanne) 
"Multi-Scale Dissection of Heterochromatin Regulation in Cancer Initiation"
 
Alaz Ozcan (University of Zurich) 
"Neutrophils Beyond the Battle: Architects of Defense"

12:30 – 13:30
Lunch Break & Industry Exhibition
13:30 – 14:30
Poster Session I

All posters exhibited  - please remain near your poster!

13:30 – 15:00
Closed Feedback Session for PIs of Tommorow

Finalists and jury only

14:30 – 16:15
Parallel Symposia Session I

The Metabolic Code of Life: Energy and Cell Systems

Speakers selected from abstracts: (10' + 2' Q&A)

Abigail Alexandre-Strefeler (University of Lausanne) 
"Uridine-sensitized screening identifies NUDT5 as a regulator of nucleotide synthesis" 
 
Sebastian Bors (University of Basel)
"A comprehensive genome-scale map of transcription factor-mediated metabolic rewiring in lung cancer via CRISPR and high-throughput metabolomics"
 
Peter Lenart (University of Bern)
"Coordinated Scaling of Germline Growth Ensures Reproductive Timing Across Environments"
 
Ryan Separovich (ETH Zurich)
"Systematic phosphoproteomics of an analog-sensitive kinase library defines context-specific signalling networks"
 
Michael Zogg (University of Basel)
"Hexose-6-phosphate dehydrogenase drives metabolic reprogramming and tumorigenicity in MDA-MB-231 triple-negative breast cancer cells"


Advances in Chemical Biology and Drug Discovery

Speakers selected from abstracts (8' + 2' Q&A):

Po-Han Chang (EPF Lausanne)
"Exploring the regulation of microtubule detyrosination and polyglutamylation through semi-synthetic tubulin"

Theodora Constantin (University of Basel)
"Covalent Inactivation of PI3Kα: Novel Paradigm for Isoform-Resolved Pharmacology"

Annemarie Ianos (Baruch College, City University of New York)
"Microtubules in Breast Cancer: Exploring the α/β-Tubulin Toggle Switch and Its Implications in Human Breast Cancer"

Kelvin Groot (University of Zurich)
"Highly multiplexed imaging uncovers combinatorial perturbation effects of small molecule treatments"

Ali Hallaj (University of Lausanne)
"A non-disruptive compound to enhance cytosolic delivery of cell-penetrating peptides"

Linda Wedemann (EPF Lausanne)
"Species-specific diacylglycerol signaling – peeking behind the mask of lipid classes"


From Disorder to Function: The Evolving Landscape of IDPs and Condensates
Marc-David RUEPP
UK Dementia Research Institute, King’s College London
Visit Ruepp's Lab Page

More about Marc-David Ruepp and this Talk

Industry speaker (5')
Valentina Millarte (Agilent Technologies AG)
"Take your real-time metabolic analysis to the next level. From 2D to 3D with the Seahorse XF FLEX analyzer"

Speakers selected from abstracts (8' + 1' Q&A):

Benjamin Frühbauer (ETH Zurich)
"Condensation of satellite DNA by the disordered protein D1 safeguards nuclear mechanostability"
 
Izabela Smok (ETH Zürich)
 "A cross-linking mass spectrometry method for characterizing protein-RNA interactions in phase-separated systems"


Ion Channels and Membrane Transporters: At the Interfaces That Fuel Life
Francesca GIORDANO
Institut de Biologie Intégrative de la Cellule (I2BC)/UMR9198
Visit Giordano's Lab Page

More about Francesca Giordano and this Talk

Speakers selected from abstracts (8' + 2' Q&A):

Alexandre Bokhobza (University of Bern)
"Optimizing MINFLUX Performance: A Pipeline for Achieving Single-Digit Nanometer Super-Resolution in Biological Samples

Marta Monguió-Tortajada (University of Lausanne)
"Relevance of the SLC15A4/TASL complex for IRF5-mediated Th1 responses"

16:15 – 16:45
Coffee Break & Industry Exhibition
16:45 – 17:20
Keynote Lecture I

Mapping new pathways of pyroptotic cell death

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Cell death is inhibited in cancers but increased in neurodegeneration, highlighting the importance of its regulation for human health. MAPL is an outer mitochondrial membrane SUMO ligase involved in cell death in both cancer and neurodegeneration in vivo, yet how MAPL controls the fate of this process remains unclear. Combining genome-wide functional genetic screening and cell biological approaches, we found that MAPL induces pyroptosis through an inflammatory pathway involving mitochondria and lysosomes. This discussion will detail the mechanisms by which MAPL and the mitochondria-to-lysosome pathway act at the nexus of immune signalling and cell death.  

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17:20 – 17:25
Introducing: The Division of Business and Economic Development of the Kanton of Zurich & Innovation Zurich Initiative
17:25 – 19:20
Industry Exhibition
17:45 – 19:20
Apéro


Thursday12.02.202608:30 – 17:20

08:30 – 09:00
Registration & Welcome Coffee

Registration will remain open until 16:00

09:00 – 09:05
Welcome Address
09:05 – 09:40
Keynote Lecture II

Looking under the hood of cells from micron to atomic scales

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Powerful new ways to image the internal structures and complex dynamics of cells are revolutionizing cell biology and bio-medical research. In my talk, I will focus on three emerging technologies capable of revealing new properties of cellular organization at scales ranging from nanometer to atomic resolution. Whole cell milling using Focused Ion Beam Electron Microscopy (FIB-SEM) was used to reconstruct the entire cell volume at 4-nm voxel resolution, revealing all membrane-bound organelles and their trafficking intermediates at isotropic resolution. Single particle tracking using Halo dyes revealed unexpected features of mRNA trafficking, including sites where secretory proteins are translated on ER and their regulation by lysosomes. Finally, High Resolution Template Matching (HRTM) of ribosome subunits in cryo-EM images of intact human cells afforded a look at ribosomes at different stages of peptide elongation at the atomic scale. Together, these new tools open-up a plethora of questions related to mechanisms of cell structure/function that can now be studied in intact cells at the nanometric/molecular level.  

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09:40 – 10:20
Coffee Break & Industry Exhibition
10:20 – 12:05
Parallel Symposia Session II

Advances in Volumetric Microscopy: from Method Development to Biological Applications

Speakers selected from abstracts (8' + 2' Q&A):

Elda Bauda (University of Geneva)
"Cryo-FIB ET uncovers novel yeast membrane compartments involved in lipid metabolism"

Laura Batti (Wyss Center for Bio and Neuro Engineering)
"Insights into whole tissue clearing and labelling protocols for various samples in a microcopy facility context"

Ruth Hornbachner (University of Zurich)
"Characterization of anterior-posterior symmetry-breaking dynamics in murine embryos using whole-mount multiplexing protein mapping"

Nikita Vladimirov (University of Zurich)
"The mesoSPIM initiative: facility-grade open-source lightsheet microscopes one can actually build"

Akanksha Jain (University of Zurich)
"Unveiling the choreography of human brain development with organoids"


Advancing Cancer Therapeutics Through Patient-Derived Complex Models

Industry speakers (20'):

Markus Koester, Menorca Chaturvedi (opnMe.com by Boehringer Ingelheim)
"Decoding KRAS with opnMe: Insights from SOS1 inhibition and other collaborative research"

Speakers selected from abstracts (8' + 2' Q&A):

Jakub Gubala (University of Geneva)
"Leveraging Multi-Organ Toxicity Models for Drug Combination Therapy Safety"
 
Gonçalo Outeiro-Pinho (University of Bern)
"MRTX1133 resistant cells rely on EZH2 activity to sustain their aggressive traits and avoid cell death"
 
Fiona Farnhammer (University Children's Hospital Zurich)
"Single enzyme activity defines response to select folate-cycle targeting drugs in osteosarcoma"
 
Evgeniya Save-Trofimenko (University of Lausanne)
"Exploiting the Rab14-Dependent Cell-Penetrating Peptide Trafficking for Targeted Chlamydia Therapy"


Proteomics in the Era of Multi-Omics
Jana SEIFERT
University of Hohenheim, Department of Functional Microbiology of Livestock
Visit Seifert's Lab Page

More about Jana Seifert and this Talk

Industry speaker (20'):

Torsten Müller (Bruker AG)
"timsMetabo for Proteomics: Bridging Omics for Deeper Biological Discovery"

Speakers selected from abstracts (8' + 2' Q&A):

Elena Barletta (Swiss Institute of Bioinformatics)
"Proteomics Profiling Reveals Sex-Based Differences and Hormonal Modulation of Recovery in Elite Female Athletes Following Intense Exercise"

Tatjana Sajic (University Hospital Lausanne)
"Biomarker discovery through in-depth characterisation of the serum protein composition of infant victims of Abusive Head Trauma (AHT)"

12:05 – 13:05
Lunch Break & Industry Exhibition
12:05 – 13:05
Physiology Section Board Meeting
12:05 – 13:05
SSEP Council Meeting
12:05 – 13:05
MCB Section Board Meeting
13:05 – 14:05
Poster Session II

All posters exhibited - please remain near your poster!

14:05 – 15:50
Parallel Symposia Session III

Mitochondria: Fueling Cells in Life, Death, and Disease

Speakers selected from abstracts (8' + 2' Q&A):

Christian Zimmerli (EPF Lausanne)
"Structure and function of unknown-intermitochondrial zipper junctions"
 
Johannes Pilic (ETH Zurich)
"Mitochondrial membrane saturation regulates mitochondrial dynamics"
 
Rosalie Heilig (University of Glasgow) 
"Mitochondrial ubiquitylation during cell death drives anti-tumorigenic pro-inflammatory signalling"
 
Marta Balkota (University of Geneva)
"Mitochondrial Glutamate Metabolism Coordinates Body Energy Balance and Age-Related Behavioral Changes"
 
Joan Blanco I Fernandez (University of Lausanne)
"Mitochondrial profiling reveals essential roles for mitochondrial DNA expression and membrane potential maintenance in IL-4/IL-13 macrophages"
 
Angela Ramos-Lobo (University of Geneva)
"Activating mutation of mitochondrial glutamate dehydrogenase in the mediobasal hypothalamus triggers seizures in mice"


Are We Coming Closer to Understanding and Treating Neurodegenerative Diseases?

Speakers selected from abstracts (8' + 2' Q&A):

Emanuele Calia (University of Fribourg)
"Molecular, genetic and functional screening to identify modifiers of MCI"

Violina Dorogan (University of Lausanne)
"Unraveling the mechanisms of neuronal communication and disposal mediated by secretory autophagy"

Simone Crivelli (University of Lausanne
"Overexpression of UCP4 in astrocytes induces fatty acid oxidation for mitochondria respiration fuelling"


Bioinformatics Driving the One Health Concept

Speakers selected from abstracts (10' + 1' Q&A):

 Carina Osterhof (University of Fribourg)
"A phylogenetic ancient, chimeric globin links oxygen sensing and flagellar motility"
 
Alexandros Taousanidis (University of Bern)
"Decoding a Structural Paradox in GH1: How Novel Mutations Drive Growth Hormone Deficiency Beyond Receptor Binding"


Extracellular vesicles in Cardiovascular Therapeutics
Philippe MENASCHE
Department of Cardiovascular Surgery, Hôpital Européen Georges Pompidou, Paris, France
Visit Menasche's Lab Page

More about Philippe Menasche and this Talk

Speakers selected from abstracts (6' + 2' Q/A):

Oksana Iamshanova (University of Fribourg)
"Bone Marrow–Derived Secretome Modulates Macrophage Polarization to Enhance Cardiac Repair"
 
Nathalie Rosenblatt-Velin (Lausanne University Hospital)
"Targeting Natriuretic Peptide Pathways to Modulate Heart and Aortic Remodeling"
 
Soumaya Es Sarhdaoui (University of Geneva)
"Role of S100A4 in Atherosclerosis Development: Focus on S100A4-expressing Cells"

15:50 – 16:10
Coffee Break & Industry Exhibition
16:10 – 16:50
Friedrich Miescher 2026 Award Lecture

Introduction by Daniel Legler

16:50 – 17:15
Award Ceremony

PIOT, Poster and Exhibition Lottery Awards

17:15 – 17:20
Closing Remarks