Program
| Wednesday | 20.04.202212:00 – 19:00 |
| 12:00 – 13:00 | Registration - Young Scientists' Satellite Below you will find the detailed schedule of the YSS, for more information of the program click here. |
Welcome Coffee | |
| 13:00 – 13:05 | Welcome Words Lydie Lane (Chairwoman of LS2 AM2022) from University of Geneva Didier Picard (President of LS2) from University of Geneva. |
| 13:05 – 13:10 | Introduction from Chairs of Satellite Lalita Oparija‐Rogenmozere (University of Melbourne. University of Zurich), |
| 13:10 – 13:45 | Keynote Lecture at YSS Simone SCHUERLE-FINKE ETH Zurich➤ Visit Schuerle-Finke's Lab Page A fantastic voyage: engineering micro-and nanorobots for medicine |
| 13:45 – 14:40 | Scientific Symposium I Short talks selected from abstracts
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| 14:40 – 15:10 | Coffee Break |
| 15:10 – 15:55 | Scientific Symposium II Short talks selected from abstracts
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| 15:55 – 16:20 | Coffee Break |
| 16:20 – 17:20 | Discussion Panel Jenny A. PRANGE MUVON Therapeutics AG. CH➤ Visit Prange's Lab Page Paulin JIRKOF University of Zurich. CH➤ Visit Jirkof's Lab Page Pedro Henrique IMENEZ SILVA University of Zurich. CH➤ Visit Imenez Silva's Lab Page Markus BRITSCHGI Section Head Neural Signalling at Roche The challenges of an international scientific career and the most important skills learnt as PhD students or young postdocs to pursue an academic vs industry career |
| 17:20 – 17:30 | Closing Remarks |
| 17:25 – 19:00 | Meet & Greet Apéro |
| Thursday | 21.04.202209:00 – 19:30 |
| 08:15 – 09:00 | Registration & Welcome Coffee |
| 09:00 – 09:10 | Welcome Words |
| 09:10 – 09:50 | Plenary Lecture I. Keynote Speaker Marnix H. MEDEMA Wageningen University, NL➤ Visit Medema's Lab Page Computational omics of plant and microbial biosynthetic diversity: from natural product discovery to microbiome ecology Plants, fungi and bacteria produce a wealth of specialized metabolites, which are of great importance from both ecological and clinical perspectives. Due to the accelerated accumulation of omics data, computational methods have become more and more important to identify these molecules and to assess their biological activities. Here, I will highlight the work performed in my research group on using these approaches to accelerate natural product discovery, as well as to study microbe-microbe and host-microbe interactions in human, plant and animal microbiomes. Specifically, I will discuss the use of computational approaches to investigate biosynthetic diversity across large numbers of genomes, and integrative genome/transcriptome/metabolome mining to associate gene clusters to molecules and ecological functions in order to elucidate the molecular basis of microbiome-associated phenotypes. Hide text… |
| 09:50 – 10:20 | Plenary Lecture II. Prix Schläfli Award Gregor WEISS ETH Zurich. CH➤ Visit Weiss' Lab Page The role of uromodulin filaments in urinary tract infections - cryoET from in vitro to patient samples Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) belong to the most common bacterial infections in humans. A crucial infection step is the adhesion of type 1-piliated UPEC to mannosylated glycoproteins on uroepithelial cells. Uromodulin (UMOD) is the most abundant protein in human urine and forms long homopolymeric filaments that antagonize UPEC adhesion, however, little was known about its structure and protective mechanism. By using an integrative approach of glyco-mass spectrometry, light microscopy, cryo-focused ion beam milling and cryo-electron tomography (cryoET), we resolved the architecture of UMOD filaments and could show how UMOD serves as a multivalent antagonist against UPEC adhesion directly in patient samples. CryoET and subtomogram averaging revealed that UMOD filaments are composed of a zigzag-shaped core module formed by the zona pellucida (ZP) domains and laterally protruding arms consisting of the N-terminal UMOD segment. We further demonstrate that UMOD forms a loose network of filaments around individual piliated bacteria and mediates the aggregation of bacteria by a dense mesh. These higher order structures likely prevent UPEC adhesion to the urinary epithelium and favor efficient clearance by micturition, representing a previously unrecognized aspect of UMOD biology. Analyzing fresh urine from patients with an acute UTI by light microscopy and cryoET confirmed our in vitro results and corroborated UMOD’s universal protective mechanism against pathogens. This demonstrates the power of cryoET to assess the molecular basis of a disease directly in patient samples. Reference Weiss, G.L., Stanisich, J.J., Sauer, M.M., Lin, C.-W., Eras, J., Zyla, D.S., Trück, J., Devuyst, O., Aebi, M., Pilhofer, M., et al. (2020). Architecture and function of human uromodulin filaments in urinary tract infections. Science 369, 1005–1010. Hide text… |
| 10:20 – 10:35 | Special Plenary Short Talk: Personalized Health More information here. Organized by the Forum for Genetic Research (SCNAT). |
| 10:35 – 11:00 | Coffee Break & Industry Exhibition |
| 11:00 – 12:50 | PIs of Tomorrow Competition Adam GOSZTOLAI EPFL. CH➤ Visit Gosztolai's Lab Page Magali HUMBERT University of Lausanne. CH➤ Visit Humbert's Lab Page Juan CARRILLO University of Fribourg. CH➤ Visit Carrillo's Lab Page Alicia MICHAEL Friedrich Miescher Institute for Biomedical Research. CH➤ Visit Michael's Lab Page More information of the PIOT competition 2022 here. PIOT chairs:
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| 12:50 – 14:15 | Lunch & Industry Exhibition Food for participants will be provided from 12:50 to 13:50. |
Feedback Session PIs of Tomorrow For jury, chairs and finalists only | |
| 14:15 – 16:00 | Plenary Short Talks from Abstracts Selected speakers from abstracts:
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| 16:00 – 16:35 | LS2 Research Slam Contest: 3' flash talks selected from abstracts
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| 16:35 – 17:30 | Coffee Break & Industry Exhibition |
LS2 Extraordinary General Assembly Lecture Hall G30 | |
| 17:30 – 19:30 | Parallel Symposia Session I |
Advances in Translational Pharmacology Andrea ALIMONTI Università della Svizzera italiana. Institute of Oncology Research. CH➤ Visit Alimonti's Lab Page Chiara AMBROGIO University of Torino. IT➤ Visit Ambrogio's Lab Page Organized by the Swiss Society of Experimental Pharmacology (SSEP) Chaired by Georgia Konstantinidou from the Institute of Pharmacology, University of Bern Speakers Selected from Abstracts:
Industry talk:
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Implication of the Circadian Clock in Sleep and Mood Regulation Urs ALBRECHT University of Fribourg. CH➤ Visit Albrecht's Lab Page Organized by the LS2 Physiology Section. Chaired by Andrea Brenna & Katrin Wendrich from University of Fribourg Selected speakers from abstracts:
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Host‐Parasite Interactomes Lucienne TRITTEN University of Zurich. CH➤ Visit Tritten's Lab Page Nicolas BRANCUCCI Swiss Tropical and Public Health Institute. CH➤ Visit Brancucci's Lab Page Organized by the Swiss Society of Tropical Medicine and Parasitology. Chaired by Pascal Maeser from The Swiss Tropical and Public Health Institute & Carmen Faso from University of Bern. Selected speaker from abstracts:
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From Genotype to Phenotype: Quantify, Integrate and Predict Joshua PAYNE ETH Zurich. CH➤ Visit Payne's Lab Page Judith ZAUGG EMBL. DE➤ Visit Zaugg's Lab Page Organized by th LS2 Systems Biology Section. Chaired by Yolanda Schaerli from University of Lausanne & Benjamin Towin from University of Bern. Speakers Selected from Abstracts:
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| Friday | 22.04.202208:50 – 18:00 |
| 08:15 – 08:50 | Registration |
| 08:50 – 09:00 | Words from Chairwoman Lydie Lane |
| 09:00 – 09:30 | Plenary Lecture III. Lelio Orci Award Markus A. RÜEGG Biozentrum, University of Basel➤ Visit Rüegg's Lab Page Investigations of the neuromuscular system: From molecular mechanisms to promising treatments for disease The largest organ of the human body is skeletal muscle, accounting for up to 50% of the entire body mass. Muscle mass and function is tightly controlled and can be lost as a consequence of pathological damage to the neuromuscular system, immobility or aging. My laboratory has studied mechanisms involved in the development and maintenance of the neuromuscular system over several decades. In particular, we are interested in how the synapse between motor neurons and muscle fibers is formed and maintained. In one of our projects, we hypothesized that extracellular matrix proteins with essential functions at the nerve-muscle synapse could be engineered to replace the function of laminin-α2, the loss of which causes a rare, early-onset muscular dystrophy. Using transgenic mouse models of the disease, we indeed demonstrated that expression of the engineered proteins strongly ameliorated the muscular dystrophy. Most strikingly, lifespan of treated mice reached more than two years whereas non-treated mice usually die within the first 4 months of life. These experiments serve as the basis for our current efforts to translate this approach into clinics using adeno-associated virus-mediated gene therapy. Hide text… |
| 09:30 – 10:00 | Coffee Break & Industry Exhibition |
| 10:00 – 12:00 | Parallel Symposia Session II |
Computational and AI‐Driven Drug/Vaccine Discovery Bruno CORREIA EPFL. CH➤ Visit Correia's Lab Page Igor STAGLJAR University of Toronto.CA➤ Visit Stagljar's Lab Page Organized by LS2 Biophysics Section. Chaired by Beat Fierz & Aleksandra Radenovic from EPFL Selected speakers from abstracts
Industry talk:
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Biochemistry in 2020s: Quantitation, Integration and Prediction Ivana GASIC University of Geneva. CH➤ Visit Gasic's Lab Page Organized by the LS2 MCB Section. Chaired by Marcus Thelen from Università della Svizzera italiana & Daniel Legler from the Biotechnologie Institut Thurgau Selected speakers from abstracts
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Handling large‐scale Complex Datasets: Integration, Modeling, Prediction Milena SOKOLOWSKA➤ Visit Sokolowska's Lab Page Catherine JUTZELER ETH Zurich. CH➤ Visit Jutzeler's Lab Page Carlos-Andrés PEÑA-REYES HEIG-VD➤ Visit Peña-Reyes' Lab Page Organized by LS2 Bioinformatics Intersection. Chaired by Katja Baerenfaller from University of Zurich & Swiss Institute of Bioinformatics. Selected speakers from abstracts:
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| 12:00 – 13:20 | Lunch & Industry Exhibition Food for participants will be provided from 12:00 ‐ 13:00 |
| 13:20 – 15:20 | Parallel Symposia Session III |
Computational Approaches for Biological Imaging Florian JUG Fondazione Human Technopole. IT➤ Visit Jug's Lab Page Anna KRESHUK EMBL. DE➤ Visit Kreshuk's Lab Page Mackenzie MATHIS EPFL. CH➤ Visit Mathis' Lab Page Organized by the LS2 Microscopy Intersection. Chaired by Arne Seitz from EPFL Selected speakers from abstracts:
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Cell Biology in the 2020s: Dynamics, Quantitation, Integration and Prediction Olivier PERTZ University of Bern. CH➤ Visit Pertz's Lab Page Anne-Claude GAVIN University of Geneva. CH➤ Visit Gavin's Lab Page Organized by the LS2 MSC Section. Chaired by Daniel Legler from the Biotechnologie Institut Thurgau & Marcus Thelen from Università della Svizzera italiana. Selected speakers from abstracts:
Industry talk:
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Combining Proteomics and Genomics for Advanced Precision Medicine Fabienne C. MEIER-ABT University Hospital Zurich➤ Visit Meier-Abt's Lab Page Christopher CLARK University of Zurich. CH Jonathan WOODSMITH Indivumed. DE Organized by the LS2 Proteomics Section. Chaired by Oliver Rinner from Biognosys Selected speakers from abstracts
Roundtable: Fabienne Meier-Abt, (University of Zurich. CH), Christopher Clark (University of Zurich. CH), Jonathan Woodsmith (Indivumed. DE) & Oliver Rinner (Biognosys. CH) | |
| 15:20 – 16:00 | Coffee Break & Industry Exhibition |
| 16:00 – 16:30 | Plenary Lecture IV. Friedrich Miescher Award Paul GUICHARD University of Geneva. CH➤ Visit Guichard's Lab Page The centriole architecture: from molecular assembly to diseases The centriole (also called basal body) is an evolutionary conserved organelle that is typically 500 nm long and 250 nm in diameter and composed of about 100 different proteins, all in multiple copies. How these proteins are organized at the level of the centriolar architecture is poorly understood and only a fraction of these proteins have been clearly studied and precisely localized. Moreover, a clear molecular overview of the centriolar structure and assembly is currently lacking. I will present the latest work from my laboratory that uses several approaches such as in vitro reconstruction, in situ cryo-tomography and high resolution molecular mapping using U-ExM to address these fundamental questions. Hide text… |
| 16:30 – 17:10 | Plenary Lecture V. Keynote Speaker Nevan KROGAN University of California San Francisco. US➤ Visit Krogan's Lab Page Host Factor Targeted Drug Discovery for SARS-CoV-2 Through an International Collaboration The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease is evolving during the current pandemic. New variants show enhanced replication and the potential to evade therapeutic antibodies. In the near future, variants may even evade first generation vaccines. The currently approved direct acting antiviral remdesivir targets the viral RNA-dependent RNA polymerase which is subject to rapid evolution as it is encoded by the viral RNA genome. In order to develop therapeutic approaches which act in a pan-coronavirus manner we and our colleagues at the QBI Coronavirus Research Group (QCRG) have mapped the human proteins (host factors) which multiple Coronaviruses rely on for replication. Through a rapid drug repurposing effort we have identified zotatifin, a clinical eIF4A inhibitor as a host factor targeted therapeutic. Zotatifin which is based on the natural product rocaglamide A works as a molecular glue to trap eIF4A on its target, the (+) RNA viral genome. Other examples of targeting essential host factors, including those for immune evasion will be discussed. Hide text… |
| 17:10 – 18:00 | Award Ceremony & Closing Remarks Announcement of LS2 Honorary Member: Marcus Thelen from Università della Svizzera italiana. Award ceremony for:
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